Our research interests
Human noroviruses are the leading cause of severe childhood diarrhea and gastroenteritis outbreaks worldwide, causing 685 million cases of acute gastroenteritis and 50,000 child deaths annually. They are difficult to study due to their strict species specificity and intractability to growth in cell culture. Consequently, our knowledge about how noroviruses cause disease is very limited. Our long-term goals are to understand norovirus pathogenesis in order to contribute to development of effective vaccines and antivirals. Using small animal models developed in the lab, our studies focus on elucidating norovirus disease mechanisms, norovirus cell and tissue tropism, and the influence of intestinal microbiota on norovirus infections.
Human noroviruses are the leading cause of severe childhood diarrhea and gastroenteritis outbreaks worldwide, causing 685 million cases of acute gastroenteritis and 50,000 child deaths annually. They are difficult to study due to their strict species specificity and intractability to growth in cell culture. Consequently, our knowledge about how noroviruses cause disease is very limited. Our long-term goals are to understand norovirus pathogenesis in order to contribute to development of effective vaccines and antivirals. Using small animal models developed in the lab, our studies focus on elucidating norovirus disease mechanisms, norovirus cell and tissue tropism, and the influence of intestinal microbiota on norovirus infections.
NOROVIRUS PATHOGENESIS NOROVIRUSES AND MICROBIOTA VIRUS-HOST INTERACTIONS
